Publications
It is a great pleasure to share our results, which have been published in a number of multidisciplinary or renowned journals
of the fields
NEURO-RELATED RESEARH
OSTEO-RELATED RESEARCH
AGE-ASSOCIATED DISEASES
PATENTS
NEURO-RELATED RESEARCH
Publications
Silva D, Barroca N, Pinto SC, Semitela A, Martins PAD, Nero L, Madarieta I, García-Urkia N, Fernández-San-Argimiro FJ, Garcia-Lizarribar A, Murua O, Olalde B, Bdikin I, Vieira SI & Marques PAAP. (2023) Decellularized extracellular matrix-based 3D nanofibrous scaffolds functionalized with polydopamine-reduced graphene oxide for neural tissue engineering. Chemical Engineering Journal. 472, 144980. DOI: 10.1016/j.cej.2023.144980
Nascimento L, Fernandes C, Silva RM, Semitela A, de Sousa BM, Marques PAAP, Vieira SI, Silva RF, Barroca N, Gonçalves G. (2023) 'Customizing 3D Structures of Vertically Aligned Carbon Nanotubes to Direct Neural Stem Cell Differentiation. Adv. Healthcare Mater. 2300828. DOI: 10.1002/adhm.202300828
Ribeiro B, Cruz B, de Sousa BM, Correia PD, David N, Rocha C, de Almeida R, da Cunha MR, Baptista AAM, Vieira SI. (2023) Cell therapies for spinal cord injury: a review of the clinical trials and cell-type therapeutic potential. Brain. 2023 Jul 3;146(7):2672-2693. DOI: 10.1093/brain/awad047
Neves D, Goodfellow BJ, Vieira SI, Silva RM. (2022) The role of NAD metabolism in neuronal differentiation. Neurochem Int. 2022. 159:105402. DOI: 10.1016/j.neuint.2022.105402
da Rocha JF, Bastos L, Domingues SC, Bento AR, Konietzko U, da Cruz E Silva OAB, Vieira SI. (2021) APP Binds to the EGFR Ligands HB-EGF and EGF, Acting Synergistically with EGF to Promote ERK Signaling and Neuritogenesis. Molecular Neurobiology, 58(2):668-688. DOI: 10.1007/s12035-020-02139-2.
Martins SA, Correia PD, Dias RA, da Cruz e Silva OAB, Vieira SI. (2019) CD81 Promotes a Migratory Phenotype in Neuronal-Like Cells. Microsc. Microanal. 25(1):229-235 DOI: 10.1017/S1431927618015532.
de Oliveira PG, Ramos MLS, Amaro AJ, Dias RA, Vieira SI. (2019) Gi/o-coupled receptors in the aging brain. Front Aging Neurosci. 11(89). DOI:10.3389/fnagi.2019.00089.
Rocha JF, da Cruz e Silva OAB, Vieira SI. (2015) Analysis of the Amyloid Precursor Protein (APP) role in neuritogenesis reveals a biphasic SH-SY5Y neuronal cell differentiation model. J. Neurochem. 134(2):288-301.
DOI: 10.1111/jnc.13133.
Dias RA, Gonçalves B, Rocha JF, da Cruz e Silva OAB, da Silva AMF, Vieira SI. (2017) NeuronRead, an open source semi-automated tool for morphometric analysis of phase contrast and fluorescence neuronal images. Mol Cell Neurosci. 85:57-69. DOI 10.1016/j.mcn.2017.08.002.
Barroca N, Marote A, Vieira SI, Almeida A, Fernandes MHV, Vilarinho PM, da Cruz e Silva OAB. (2018) Electrically polarized PLLA nanofibers as neural tissue engineering scaffolds with improved neuritogenesis. Colloids Surf B Biointerfaces 167:93-103. DOI: 10.1016/j.colsurfb.2018.03.050.
Marote A, Barroca N, Vitorino R, Silva RM, Fernandes MHV, Vilarinho PM, da Cruz e Silva OAB, Vieira SI. (2016) A proteomic analysis of the interactions between poly(L-Lactic Acid) nanofibers and SH-SY5Y neuronal-like cells. AIMS Molecular Science (special issue: Cells Signalling and Signal Transduction). 3(4):661-682.
DOI: 10.3934/molsci.2016.4.661.
Rocha JF, Vieira SI, da Cruz e Silva, OAB. (2012) APP phosphorylation at S655 correlates with F-actin cytoskeleton dynamics – relevance in neuronal differentiation. Microsc. Microanal. 18(S5):57-58. DOI:10.1017/S1431927612012949.
Pinho AC, Dias R, Cerqueira AR, da Cruz e Silva OAB, Vieira SI. (2015) APP and its secreted fragment sAPP in SH-SY5Y neuronal-like migration. Microsc. Microanal. 21(S6):36-37. DOI:10.1017/S1431927614013853.
Resende M & Vieira SI. (2012) G Proteins in Signal Transduction. In Fardilha M, Conde M, da Cruz e Silva OAB, The eSSential on Signal Transduction / O eSSensial em Sinalização Celular (p. 94-129), Aveiro: “Ed Biologicando”, Dept. Biologia, Universidade de Aveiro & Edições Afrontamento. ISBN: 9789723612530 (book chapter available upon request to SI Vieira).
Vieira SI, Rebelo S, Esselmann H, Wiltfang J, Lah J, Lane R, Small SA, Gandy S, da Cruz e Silva EF, da Cruz e Silva OAB. (2010) Retrieval of the Alzheimer’s amyloid precursor protein from the endosome to the TGN is S655 phosphorylation state-dependent and retromer-mediated. Mol. Neurodegener. 5:40.
DOI: 10.1186/1750-1326-5-40.
da Cruz e Silva OAB, Rebelo S, Vieira SI, Gandy S, da Cruz e Silva EF, Greengard P. (2009) Enhanced generation of Alzheimer’s amyloid- beta following chronic exposure to phorbol ester correlates with differential effects on alpha and epsilon isozymes of protein kinase C. J. Neurochem. 108:319-330. DOI: 10.1111/j.1471-4159.2008.05770.x
Vieira SI, Rebelo S, Domingues ST, da Cruz e Silva EF, da Cruz e Silva OAB. (2009) S655 Phosphorylation Enhances APP Secretory Traffic. Mol. Cell. Biochem. 328:145-54. DOI: 10.1007/s11010-009-0084-7.
OSTEO-RELATED RESEARCH
Publications
Figueiredo JGS, de Sousa BM, Soares dos Santos MP, Vieira SI. (2024) Gathering evidence to leverage musculoskeletal magnetic stimulation towards clinical applicability. Small Science. DOI: 10.1002/smsc.202300303
Bjørge IM, de Sousa BM, Patrício SG, Silva AS, Nogueira LP, Santos LF, Vieira SI, Haugen HJ, Correia CR, Mano JF. (2022) Bioengineered hierarchical bone-like compartmentalized microconstructs using nanogrooved microdiscs. ACS Appl. Mater. Interfaces. 14(17):19116–19128. DOI: 10.1021/acsami.2c01161
Baptista IO, Alves MFRP, Ferreira S, Santos C, Vieira SI, Fernandes MHV. (2022) Antibacterial activity improvement of dental glass-ceramic by incorporation of AgVO3 nanoparticles. Dent Mater. 2022, 38(11):1679-1688. DOI: 10.1016/j.dental.2022.08.009
de Sousa BM, Correia CR, Ferreira JAF, Mano JF, Furlani EP, Soares dos Santos MP, Vieira SI. (2021) Capacitive interdigitated system of high osteoinductive/conductive performance for personalized acting-sensing implants. npj Regenerative Medicine. 6, 80. DOI: 10.1038/s41536-021-00184-6
Soares dos Santos MP, Coutinho J, Marote A, Sousa B, Ramos A, Ferreira JAF, Bernardo R, Rodrigues A, Marques AT, da Cruz e Silva OAB, Furlani EP, Simões JAO, Vieira SI. (2019) Capacitive technologies for highly controlled and personalized electrical stimulation by implantable biomedical systems. Scientific Reports. 9, 5001. DOI: 10.1038/s41598-019-41540-3.
Marques C, Olhero S, Abrantes JCC, Marote A, Ferreira S, Vieira SI, Ferreira JMF. 2017. Biocompatibility and antimicrobial activity of biphasic calcium phosphate powders doped with metal ions for regenerative medicine. Ceramics International. 43(17):15719-15728. DOI: 10.1016/j.ceramint.2017.08.133.
Torres PMC, Marote A, Cerqueira AR, Calado AJ, Abrantes JCC, Olhero S, da Cruz e Silva OAB, Ferreira JMF, Vieira SI. (2017) Injectable MnSr-doped brushite bone cements with improved biological performance. J. Mater. Chem. B. 5: 2775-2787. DOI: 10.1039/C6TB03119F.
Marques C, Perera FH, Marote A, Ferreira S, Vieira SI, Olhero S, Miranda P, Ferreira JMF. (2016) Biphasic calcium phosphate scaffolds fabricated by direct write assembly: mechanical, anti-microbial and osteoblastic properties. J European Ceramic Society. 37(1):359–368.
DOI: 10.1016/j.jeurceramsoc.2016.08.018
Soares dos Santos MP, Marote A, Santos T, Torrão J, Ramos A, Simões JAO, da Cruz e Silva OAB, Furlani EP, Ferreira JAF, Vieira SI. (2016) New cosurface capacitive stimulators for the development of active osseointegrative implantable devices. Scientific Reports. 6, 30231. DOI: 10.1038/srep30231.
Marques CF, Lemos A, Vieira SI, da Cruz e Silva OAB, Bettencourt A, Ferreira JMF. (2016) Antibiotic-loaded Sr-doped porous calcium phosphate granules as multifunctional bone grafts. Ceramics International. 42(2A):2706–16. DOI: 10.1016/j.ceramint.2015.11.001.
Torres PMC, Vieira SI, Cerqueira AR, Pina S, da Cruz e Silva OAB, Abrantes JCC, Ferreira JMF. (2014) Effects of Mn-doping on the structure and biological properties of β-tricalcium phosphate. Journal of Inorganic Biochemistry. 136:57-66. DOI:10.1016/j.jinorgbio.2014.03.013.
Kannan S, Vieira SI, Olhero SM, Torres PM, Pina S, da Cruz E Silva OA, Ferreira JM. (2011) Synthesis, mechanical and biological characterization of ionic doped carbonated hydroxyapatite/β-tricalcium phosphate mixtures. Acta Biomater. 7(4):1835-1843. DOI: 10.1016/j.actbio.2010.12.009.
Vieira SI, Pina S, Rego P, Torres PMC, da Cruz e Silva OAB, Cruz e Silva EF, Ferreira JMF. (2010) Biological responses of brushite-forming Zn- and ZnSr-substituted β-tricalcium phosphate bone cements. European Cells and Materials. 20:162-177. DOI:10.22203/eCM.v020a14.
Vieira SI, Pina S, Torres PMC, Goetz-Neunhoeffer F, Neubauer J, da Cruz e Silva OAB, Cruz e Silva EF, Ferreira JMF. (2010) In vitro performance assessment of new brushite-forming Zn- and ZnSr-substituted β-TCP bone cements. J Biomed Mater Res B Appl Biomater. 94(2):414-20. DOI: 10.1002/jbm.b.31669.
AGE-ASSOCIATED DISEASES
& OTHER TOPICS
Publications
Gouveia M, Schmidt C, Basilio PG, Aveiro SS, Domingues P, Xia K, Colón W, Vitorino R, Ferreira R, Santos M, Vieira SI*, Ribeiro F*. (2023) Exercise training decreases the load and changes the content of circulating SDS-resistant protein aggregates in patients with heart failure with reduced ejection fraction. Mol Cell Biochem. DOI:10.1007/s11010-023-04884-z
Gouveia M, Teixeira M, Schmidt C, Lopes M, Trindade D, Magalhães S, Henriques AG, Nunes A, Santos M, Vieira S, Ribeiro F. (2023) Impaired extracellular proteostasis in patients with heart failure. Archives of Medical Research. DOI:10.1016/j.arcmed.2023.02.001
Ferreira JRM, Alves M, Sousa B, Vieira SI, Silva AMS, Guieu S, Cunha Â, Nunes da Silva R. (2023) Curcumin-based molecular probes for fluorescence imaging of fungi. Org Biomol Chem. 2023, 21(7):1531-1536.
DOI: 10.1039/d2ob01872a
Gouveia M, Schmidt C, Teixeira M, Lopes M, Aveiro SS, Domingues P, Xia K, Colón W, Vitorino R, Ferreira R, Santos M, Vieira S, Ribeiro F. (2022) Characterization of Plasma SDS-Protein Aggregation Profile of Patients with Heart Failure with Preserved Ejection Fraction. J Cardiovasc Transl Res.
DOI: 10.1007/s12265-022-10334-w.
Vieira SI, Nunes da Silva R, Alves M, Dias RA, Sousa AMM, Camões F, Maia A, Almeida M, Rocha J, Silva AMS, Guieu S. (2022) Liprobe, a vital dye for lipid aggregates detection in imaging and high-content screens. Front. Photonics. 3:963778. DOI: 10.3389/fphot.2022.963778
Teixeira M, Trindade D, Gouveia M, Eller-Borges R, Magalhães S, Duarte A, Ferreira M, Simões MI, Conceição M, Nunes A, Henriques AG, Ribeiro F*, Vieira SI*. (2022) Proteostasis Response to Protein Misfolding in Controlled Hypertension. Cells. 19;11(10):1686. DOI: 10.3390/cells11101686.
Albuquerque HMT, Nunes da Silva R, Pereira M, Maia A, Guieu S, Soares AR, Santos CMM, Vieira SI, Silva AMS. (2022) Steroid–Quinoline Hybrids for Disruption and Reversion of Protein Aggregation Processes. ACS Medicinal Chemistry Letters. 13(3):443–448. DOI: 10.1021/acsmedchemlett.1c00604.
Santos CIM, Rodríguez-Pérez L, Gonçalves G, Dias CJ, Monteiro F, Faustino M do AF, Vieira SI, Helguero LA, Herranz MÁ, Martin N, Neves MGPMS, Martinho JMG, Maçõas EMS. (2021) Enhanced Photodynamic Therapy Effects of Graphene Quantum Dots Conjugated With Aminoporphyrins. ACS Applied Nano Materials. 4(12):13079–89. DOI: 10.1021/acsanm.1c02600.
Gomes C, Ferreira D, Carvalho JPF, Barreto CAV, Fernandes J, Gouveia M, Ribeiro F, Duque AS, Vieira SI. (2020) Current genetic engineering strategies for the production of antihypertensive ACEI peptides. Biotechnol Bioeng. 117(8):2610-2628. DOI: 10.1002/bit.27373.
Teixeira M, Gouveia M, Duarte A, Ferreira M, Simões IM, Conceição M, Silva G, Magalhães S, Ferreira R, Nunes A, Vieira SI, Ribeiro F. (2019) Regular exercise participation contributes to better proteostasis, inflammatory and vasoactive profiles in patients with hypertension. Am J Hypertension. 33(2):119-123
DOI: 10.1093/ajh/hpz160.
Nunes da Silva R, Costa CC, Santos MJG, Alves MQ, Braga SS, Vieira SI, Rocha J, Silva AMS, Guieu S. (2019) Fluorescent Light-up Probe for the Detection of Protein Aggregates. Chem Asian J. 14(6): 859-863. DOI: 10.1002/asia.201801606.
Gomes C, Oliveira F, Vieira SI, Duque AS. (2019) Prospects for the production of recombinant therapeutic proteins and peptides in plants: special focus on angiotensin I–converting enzyme inhibitory (ACEI) peptides. (pp.27); In Genetic Engineering, INTECHOPEN, Prof. Farruhk Jamal Ed. ISBN 978-953-953-51-7062-4.
Santos CIM, Gonçalves G, Cicuéndez M, Mariz I, Silva VS, Oliveira H, Campos F, Vieira SI, Marques PAAP, Maçôas EMS, Neves MGPMS, Martinho JMG. (2018) Biocompatible hybrids based on nanographene oxide covalently linked to glycolporphyrins: Synthesis, characterization and biological evaluation. Carbon 135:202-14. DOI: 10.1016/j.carbon.2018.04.040.
Gouveia M, Xia K, Colón W, Vieira SI, Ribeiro F. (2017) Protein aggregation, cardiovascular diseases, and exercise training: where do we stand? Ageing Res Rev. 40:1-10. DOI: 10.1016/j.arr.2017.07.005.
Frommlet JC, Sousa ML, Alves A, Vieira SI, Suggett DJ, Serôdio J. (2015) Coral symbiotic algae calcify ex hospite in partnership with bacteria. PNAS. 112(19):6158–6163. DOI: 10.1073/pnas.1420991112.
PATENTS
National & International
Patents on “PKMYT1 for use in regenerative medicine”:
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International (EU) patent application no. EP22203135.3, submitted to the European Patent Office (EPO) at 2022.10.21.
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National (PT) patent application no. 118269, published by to the Portuguese Institute of Industrial Property (INPI) at 2024.04.22.
Patents on Fluorescent compounds, production methods and uses thereof (fluorescent probes for lipid aggregates, for cell-based high-content screening):
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International patent EP3445348 (A1), published at 2019-02-27.
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International patent WO/2017/182945 A1, published at 2017.10.26.
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National patent PT109330 (A), published at 2017.10.18 in ‘Boletim da Propriedade Industrial nr 203/2017’.