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Trabalhador de laboratório

Research lines

Find out the main topics of the interdisciplinary research areas we work in, and the projects that support them

Spark Lab: Bem-vindo
Research line 1 - RAGs and common DEGs network

NEUROREGENERATION & NEUROREHABILITATON

  • Signaling and OMICs (transcriptomics, proteomics, microbiomics)

  • Neuronal differentiation, neuritogenic mechanisms, neurotrophic factors

  • Spinal cord injury (biomarkers, gene and cell therapies, determinants of rehabilitation)

  • New biomaterials for neuroregeneration

  • Electrical stimulation for neuroregeneration

  • Neurodegeneration (e.g. Alzheimer’s disease)

  • Basic to Clinical Research

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Projects:

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  • GoBack - 'New therapeutic targets for spinal cord regeneration' (PTDC/CVT-CVT/32261/2017 and CENTRO-01-0145-FEDER-032261)

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  • Proteomics in SCI - 'Proteomic profiling of serum and cerebrospinal fluid to identify candidate biomarkers of Spinal Cord Injury severity and prognosis' (EPIC-XS-0000379):  epic-xs.eu

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  • ProTmedula - 'Temporal profile of regeneration markers in samples from patients with spinal cord injury', in MEDISIS (CENTRO-01-0246-FEDER-000018)

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  • SCIMBIONT - 'Spinal Cord Injury Rehabilitation: Gut dysbiosis and immune biomarkers as functional prognosis tools and new therapeutic targets', in MEDISIS (CENTRO-01-0246-FEDER-000018)

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  • NeuroStimSpinal - 'A step forward to spinal cord injury repair using innovative stimulated nanoengineered scaffolds' (EU FETOPEN G.A. No: 829060)

OSTEOREGENERATION & MUSCULOSKELETAL REHABILITATON

  • Biomaterials: chemical, physical and topographic cues

  • Doped ceramics and other biomaterials, dental prostheses

  • Instrumented active bone prostheses (sensors, actuators)

  • Electrical stimulation for osteoregeneration

  • Fractures, Osteoporosis, Vertebral pathologies

  • Basic to Clinical Research

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Projects:

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  • STIMULUS - 'In-vitro evaluation of stimulation methods for bone regeneration around orthopaedic implants' (EXPL/EMS-SIS/2128/2013)

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  • PPBI bioimaging (PPBI-POCI-01-0145-FEDER-02212)

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  • FLEXOBONE - 'Flexoelectricity for engineering osteoinductive electromechanical transducers' (FCT 2022.02424.PTDC)

Research line 2 - controlo 30div f-actin colag dapi f6 pm copy.tif
Research Line 3 Clinical Research

PROTEOSTASIS IN AGING AND DISEASES

  • Aging and Proteostasis in cardiovascular and nervous systems

  • Proteostasis in Hypertension and Heart failure

  • Proteostasis in Spinal cord injury and Alzheimer’s disease

  • New chemicals for detection and disaggregation of protein and lipid aggregates

  • Pharming new anti-hypertensive peptides

  • Basic and Clinical Research

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Projects:

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  • 'The impact of viral infections on the development of neurodegenerative diseases: investigation of cellular and molecular mechanisms' (colaboration between Brazilian Universities and UAveiro)

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  • pAGE - 'Protein Aggregation across the lifespan' (CENTRO-01-0145-FEDER-000003)

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  • Exercise intervention in heart failure (POCI-01-0145-FEDER-030011)

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  • LipidPro (Prove it 2ª Ed UA/CampusTEC/Centro2020)

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  • F'Marker (P2020, nº 17351, 17/SI/2015), Angelini Award (2012/2013 AUA!, 4º Ed)

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  • ProTmedula/MEDISIS (CENTRO-01-0246-FEDER-000018)​

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  • EPIC-XS - 'Are Exosomes Mediating the Positive Effects of Exercise Training in Patient with Heart Failure?' (EPIC-XS-0000219)

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